The first human safety trial of NMN in humans was published in 2019 and showed that a single dose of up to 500mg was tolerable.NMN has been proven safe in high dosages up to 1.2g a day in human clinical studies. Furthermore, multiple health benefits have been demonstrated in humans as well.

A study in prediabetic, postmenopausal, obese or overweight women showed that after 10 weeks of NMN supplementation, the volunteers had increased insulin sensitivity. Same study showed that NMN supplementation was able to stimulate the collagen production pathway, suggesting the compound's role in healthy aging (and appearance of skin).

A study in elderly men over 65 showed that NMN supplementation protects against age-related muscle loss. Another study in healthy, adult volunteers of both sexes confirmed that NMN increases endurance, cardiovascular fitness and aerobic capacity in amateur runners.

You can learn more about the benefits of NMN through this article: Everything You Need to Know About NMN Supplement

It is recommended to take NMN before breakfast to ensure maximum absorption by your body.

If you are under 35, start with 250 mg per day and increase to 500 mg after 1-2 weeks to see how you feel.

If you are over 35, start with 500 mg per day and then increase to 1 gram, depending on how you feel.

Not recommended. Taking NMN all at once in the morning will sync your NMN intake with your circadian rhythm.

Dr. David Sinclair and our Chief Scientific Advisor, Professor Michael Levitt, recommend taking the capsules as is. In fact, there are no studies that show that sublingual powders or other forms of powder ingestion are better absorbed than capsules.

The reason is also explained in a section of this article:Choosing the Best NMN Supplement: What You Need to Know

In addition to taking NMN, you can also take a tablespoon of extra virgin olive oil in the morning. Oleic acid, a component of olive oil, has also been shown to activate SIRTUINS, the so-called longevity genes.

In addition, by supplementing with TMG (trimethylglycine), you can increase the available methyl groups in your cells (which NMN utilizes). Adding TMG to your NMN supplement is an excellent way to increase the efficiency of NMN and ensure balanced homocysteine ​​levels.

Of course, the best thing is to maintain a sufficient exercise habit and a reasonable diet.