The Sirtuin gene family consists of seven genes from SIRT1 to SIRT7. Sirtuin proteins act as NAD+-dependent deacetylases. Particularly, SIRT3 located in mitochondria is believed to be closely related to periodontal disease. According to the report from the National Institutes of Health in the United States, elderly mice lacking SIRT3 showed faster deterioration of periodontal disease compared to mice under other conditions.
The aim of this study was to elucidate the effect of SIRT3 on periodontal disease in the elderly and its mechanism. Therefore, a method comparing mice with SIRT3 gene deletion (KO) to normal mice (WT) was employed. Since the experiment involved young and aged periods, comparative analyses were conducted on four groups: WT-Young, KO-Young, WT-Aged, and KO-Aged.
The analysis results indicate that in WT-Aged (normal elderly) mice, the content of SIRT3 in the alveolar bone decreased compared to WT-Young (normal young) mice, suggesting a decrease in SIRT3 function with aging. Moreover, KO-Aged (SIRT3-deficient elderly) mice showed the highest bone resorption assay values in the alveolar bone compared to the other four groups, indicating actual bone loss. Based on these results, it is suggested that the reduction of alveolar bone in age-related periodontal disease may be due to the deterioration of bone metabolism caused by the decreased function of SIRT3, leading to a direction towards bone resorption.
Furthermore, it was found that with the decrease in SIRT3 function, mitochondrial function in gingival tissue weakened, and damage from reactive oxygen species increased. This also suggests a significant impact of decreased SIRT3 function on the progression of age-related periodontal disease.
Moreover, playing a role in the activation of Sirtuin genes including SIRT3 in bodily tissues is NAD+ (nicotinamide adenine dinucleotide). However, it is understood that NAD+ decreases with age. To restore or increase NAD+ levels in the body, methods such as exercise or calorie restriction can be employed, but this may be accompanied by physical and mental stress. Therefore, the focus is on the precursor of NAD+, namely the intake of the new paradigm of anti-aging care, "NMN", which can help restore and increase NAD+ levels.
NMN is also a component present in all biological cells, similar to NAD+, and its production gradually decreases with age. Although NMN can be obtained through food intake, the amount is minimal, so intake via supplements or intravenous injection is an efficient and common method.
In this context, AIDEVI NMN Supplements, such as NMN 18000 supplements or NMN 21000 supplements, play a crucial role in maintaining oral health and combating age-related periodontal disease.