Cardiovascular diseases pose a serious threat to people's health and have become the second leading cause of death in USA, following only cancer.
1. Delaying Vascular Aging with NMN
NMN activates Sirtuins in our bodies, also known as silent regulator proteins. They play a crucial regulatory role in growth, development, aging, and various diseases by regulating the acetylation levels of multiple proteins in cells. Recent research has found that Sirtuins are closely involved in vascular remodeling diseases.NMN, when taken orally, can be rapidly absorbed by the body and penetrate cell membranes. This allows NMN to synthesize NAD+ within cells, increasing the level of NAD+ in the body. Consequently, it can reverse the aging process of blood vessels, acting on the prevention and improvement of cardiovascular diseases.
2. Preventing Stroke with NMN
Stroke is the most common type of cerebrovascular disease, accounting for about 70% of all acute cerebrovascular diseases, with a higher prevalence in middle-aged and elderly individuals. In recent years, researchers have found that NMN can prevent strokes by improving the dilation of vascular endothelial cells and promoting blood circulation.NMN, upon entering cells, effectively increases the levels of NAD+. Elevated NAD+ levels enhance SIRTUINS expression, reducing mitochondrial attacks by free radicals, maintaining mitochondrial function, and allowing the production of nitric oxide. Nitric oxide is crucial for vasodilation, which significantly improves blood vessel dilation, thereby promoting circulation in the cardiovascular system and enhancing cognitive function.
3. Alleviating Brain Hemorrhage Damage with NMN
Intracerebral hemorrhage (ICH) is a primary brain injury caused by mechanical damage, leading to bleeding. It can sometimes progress to secondary damage, mainly due to subsequent pathophysiological changes, including blood-brain barrier (BBB) disruption, hemoglobin-induced iron overload, neuronal death, neuroinflammation, and oxidative stress. Research has found that NMN can protect brain neurons and promote vascular nerve regeneration, exerting a good repair effect on brain hemorrhage and its neurological damage.Additionally, scientific teams have found that NMN enhances the expression of cell-protective proteins, inhibits brain neuroinflammation and oxidative stress, thereby reducing post-hemorrhagic brain damage.
4. Preventing Arteriosclerosis with NMN
Healthy arteries are elastic, but over time, the arterial walls stiffen, a condition known as arteriosclerosis. Studies have shown that NMN can reverse the levels of a substance called MIRNA in blood vessels, leading to epigenetic rejuvenation and resistance to atherosclerosis, thus preventing vascular aging.5. Improving Aging of Vascular Smooth Muscle
Vascular aging is a direct cause of organismal aging, and maintaining youthful blood vessels has become a focus in the field of aging inhibition. Research has demonstrated that NMN supplementation or CD38 inhibition can elevate NAD+ levels, delay vascular smooth muscle cell aging, and prevent pathological structural changes.Furthermore, studies have shown that NMN supplementation in mice can improve arterial stiffness and elasticity, enhancing vascular resilience.