nmn18000 NMN Cardiovascular Diseases

NMN Cardiovascular Diseases

Cardiovascular diseases pose a serious threat to people's health and have become the second leading cause of death in USA, following only cancer.

NMN Cardiovascular Diseases

1. Delaying Vascular Aging with NMN

NMN activates Sirtuins in our bodies, also known as silent regulator proteins. They play a crucial regulatory role in growth, development, aging, and various diseases by regulating the acetylation levels of multiple proteins in cells. Recent research has found that Sirtuins are closely involved in vascular remodeling diseases.

NMN, when taken orally, can be rapidly absorbed by the body and penetrate cell membranes. This allows NMN to synthesize NAD+ within cells, increasing the level of NAD+ in the body. Consequently, it can reverse the aging process of blood vessels, acting on the prevention and improvement of cardiovascular diseases.

2. Preventing Stroke with NMN

Stroke is the most common type of cerebrovascular disease, accounting for about 70% of all acute cerebrovascular diseases, with a higher prevalence in middle-aged and elderly individuals. In recent years, researchers have found that NMN can prevent strokes by improving the dilation of vascular endothelial cells and promoting blood circulation.

NMN, upon entering cells, effectively increases the levels of NAD+. Elevated NAD+ levels enhance SIRTUINS expression, reducing mitochondrial attacks by free radicals, maintaining mitochondrial function, and allowing the production of nitric oxide. Nitric oxide is crucial for vasodilation, which significantly improves blood vessel dilation, thereby promoting circulation in the cardiovascular system and enhancing cognitive function.

3. Alleviating Brain Hemorrhage Damage with NMN

Intracerebral hemorrhage (ICH) is a primary brain injury caused by mechanical damage, leading to bleeding. It can sometimes progress to secondary damage, mainly due to subsequent pathophysiological changes, including blood-brain barrier (BBB) disruption, hemoglobin-induced iron overload, neuronal death, neuroinflammation, and oxidative stress. Research has found that NMN can protect brain neurons and promote vascular nerve regeneration, exerting a good repair effect on brain hemorrhage and its neurological damage.

Additionally, scientific teams have found that NMN enhances the expression of cell-protective proteins, inhibits brain neuroinflammation and oxidative stress, thereby reducing post-hemorrhagic brain damage.

4. Preventing Arteriosclerosis with NMN

Healthy arteries are elastic, but over time, the arterial walls stiffen, a condition known as arteriosclerosis. Studies have shown that NMN can reverse the levels of a substance called MIRNA in blood vessels, leading to epigenetic rejuvenation and resistance to atherosclerosis, thus preventing vascular aging.

5. Improving Aging of Vascular Smooth Muscle

Vascular aging is a direct cause of organismal aging, and maintaining youthful blood vessels has become a focus in the field of aging inhibition. Research has demonstrated that NMN supplementation or CD38 inhibition can elevate NAD+ levels, delay vascular smooth muscle cell aging, and prevent pathological structural changes.

Furthermore, studies have shown that NMN supplementation in mice can improve arterial stiffness and elasticity, enhancing vascular resilience.

6. Mitigating Heart Dysfunction Due to Echs1 Deficiency with NMN

Echs1 (enoyl-CoA hydratase short chain 1) deficiency is closely related to the occurrence of cardiomyopathy. Researchers have found that NMN can mediate histone acetylation, thus targeting the prevention of Echs1 deficiency-related cardiomyopathy development, potentially serving as a preventive measure against cardiomyopathy.

7. Reducing Arterial Stiffness in Aging Mice with NMN

Scientists discovered that feeding aged mice NMN reduced arterial stiffness, improving vessel wall elasticity, akin to younger mice. NMN supplementation increased elastic proteins and decreased load proteins in aged mice, demonstrating its ability to enhance vascular elasticity in aging vessel walls.

8. Improving Metabolism and Function of Aging Hearts

Research from the University of Washington in 2020 tested the effects of two mitochondrial-targeted drugs, SS-31 and NMN, on aging hearts. While SS-31 partially reversed age-related diastolic dysfunction, NMN completely reversed age-related cardiac systolic dysfunction, showing a synergistic effect in revitalizing aging hearts.

9. Alleviating Cardiac Fibrosis

Coronary atherosclerosis, cardiac metabolic abnormalities, myocardial ischemia, among other factors, can lead to cardiac fibrosis, resulting in abnormal stiffening of the heart and eventual heart failure. NMN supplementation has been shown to have significant protective effects on blood vessels, reducing cardiovascular diseases, and improving heart and vascular dysfunction.

NMN supplementation comprehensively revitalizes the cardiovascular system and plays a significant role in the prevention and treatment of cardiovascular diseases.

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